In a clinical study using fluorescence measurements, blueberry extract in the presence of ribose as a reducing sugar had a similar dose response to positive control aminoguanidine, a potent glycation inhibitor. In addition, in reconstructed skin containing collagen modified by glycation, treatment with blueberry extract diminished CML antibodies (one of the A.G.E.s found in chronologically aged skin in-vivo), and returned previously over-expressed biomarkers to a normal pattern of distribution. These results indicate a return to skin’s normal morphological structure.
A controlled12-week clinical study of A.G.E. Interrupter on 43 women ages 45-61 revealed improvement in skin texture, fine lines, and wrinkles.